奥沙利铂溶液的水解氧化机制及稳定性研究进展

曾春颖,,陆萧筠,,梅兴国*

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (5) : 326-330.

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PDF(1194 KB)
中国药学杂志 ›› 2013, Vol. 48 ›› Issue (5) : 326-330. DOI: 10.11669/cpj.2013.05.002
综 述

奥沙利铂溶液的水解氧化机制及稳定性研究进展

  • 曾春颖1,2,陆萧筠1,2,梅兴国2*
作者信息 +
文章历史 +

摘要

目的 综述导致奥沙利铂水溶液水解及氧化的机制及稳定性方面的研究进展。方法 查阅国内外相关文献并进行分析综述。结果 奥沙利铂溶液是个复杂的系统,溶液中的多种物质易与奥沙利铂发生相互作用而发生水解氧化等反应,且反应产物大多无药理活性。笔者综述了解决奥沙利铂水溶液稳定性的几种最新方法。结论 随着对奥沙利铂水溶液稳定性的不断深入研究以及奥沙利铂创新剂型的不断涌现,相信会促使更多更有效地新制剂满足安全性,走向临床。

关键词

奥沙利铂 / 水解 / 氧化 / 稳定性 / 药品采购

引用本文

导出引用
曾春颖,,陆萧筠,,梅兴国*. 奥沙利铂溶液的水解氧化机制及稳定性研究进展[J]. 中国药学杂志, 2013, 48(5): 326-330 https://doi.org/10.11669/cpj.2013.05.002
中图分类号: R944   

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